Publications

Litke C, Hagenston AM, Kenkel A-K, Paldy E, Lu J, Kuner R, Mauceri D. Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice. Nat Commun 13, 875 (2022). DOI: https://doi.org/10.1038/s41467-022-28357-x. Press release from Heidelberg University:  https://www.uni-heidelberg.de/en/newsroom/how-chronic-pain-arises

Mauceri D. Role of epigenetic mechanisms in chronic pain. Cells. 11, 2022 Aug 22;11(16):2613.  doi: 10.3390/cells11162613.

Vieira JR, Shah B, Dupraz S, Paredes I, Himmels P, Schermann G, Adler H, Motta A, Gärtner L, Navarro-Aragall A, Ioannou E, Dyukova E, Bonnavion R, Fischer A, Bonanomi D, Bradke F, Ruhrberg C, Ruiz de Almodovar C. Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development. Neuron. 2022 Dec 21;110(24):4074-4089.e6. doi: 10.1016/j.neuron.2022.12.005.

Simonetti M, Paldy E, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R. The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology. Mol Psychiatry. 2021 Apr;26(4):1376-1398. doi: 10.1038/s41380-019-0491-4.

Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J. Reciprocal interactions between vascular filopodia and neural stem cells shapes neurogenesis in the ventral telencephalon. Cell Reports. 2020 Oct 13;33(2):108256. doi: 10.1016/j.celrep.2020.108256.

Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C. Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 2021 Apr;24(4):478-488.  doi: 10.1038/s41593-020-00788-z. Epub 2021 Jan 28.

Shen Y, Wang X, Lu J, Salfenmoser M, Wirsik NM, Schleussner N, Imle A, Freire Valls A, Radhakrishnan P, Liang J, Wang G, Muley T, Schneider M, Ruiz de Almodovar C, Diz-Muñoz A & Schmidt T. Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer. Cancer Cell. 2020 Jun 8;37(6):800-817.

Maurer J, Yanez A, Bengtson CP, Bading H, Draguhn A, Mauceri D, VEGF-D Downregulation in CA1 Pyramidal Neurons Exerts Asymmetric Changes of Dendritic Morphology without Correlated Electrophysiological Alterations. M. Neuroscience 448:28-42 2020.

Pelucchi S, Vandermeulen L, Pizzamiglio L, Aksan B, Yan J, Konietzny A, Bonomi E, Borroni B, Rust MB, Di Marino D, Mikhaylova M, Mauceri D, Antonucci F, Gardoni F, Di Luca M, Marcello E, CAP2 dimer controls structural synaptic plasticity by regulating cofilin localization in spines. Brain Comm 2(2):fcaa086, 2020.

Pelucchi S, Vandermeulen L, Pizzamiglio L, Aksan B, Yan J, Konietzny A, Bonomi E, Borroni B, Padovani A, Rust MB, Di Marino D, Mikhaylova M, Mauceri D, Antonucci F, Edefonti V, Gardoni F, Di Luca M, Marcello E. Cyclase-associated protein 2 dimerization regulates cofilin in synaptic plasticity and Alzheimer’s disease. Brain Commun. 2020 Jun 26;2(2):fcaa086. doi: 10.1093/braincomms/fcaa086.

Maurer J, Yanez A, Bengtson CP, Bading H, Draguhn A, Mauceri D, Both M. VEGF-D Downregulation in CA1 Pyramidal Neurons Exerts Asymmetric Changes of Dendritic Morphology without Correlated Electrophysiological Alterations. Neuroscience. 2020 Nov 10;448:28-42. doi: 10.1016/j.neuroscience.2020.09.012.
 
Mauceri D, Buchthal B, Hemstedt TJ, Weiss U, Klein CD, Bading H. Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage. Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8616-8623. doi: 10.1073/pnas.2001563117 (Press release).

Vieira JR, Shah B, Ruiz de Almodovar C. Cellular and molecular mechanisms of spinal cord vascularization. Front Physiol 2020. Dec 21; 11:599897. DOI: 10.3389/fphys.2020.599897

Schlüter A, Aksan B, Diem R, Fairless R, Mauceri D.VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injury. Mol Therapy MCD 17, 281-299, 2020.

Carrano N, Samaddar T, Brunialti E, Franchini L, Marcello E, Ciana P, Mauceri D, Di Luca M, Gardoni F. The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal Morphology. Mol Neurobiol. 2019 Nov;56(11):7583-7593. doi: 10.1007/s12035-019-1631-1.

Harde E, Nicholson L, Furones Cuadrado B, Bissen D, Wigge S, Urban S, Segarra M, Ruiz de Almodóvar C, Acker-Palmer A. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. Elife. 2019 Dec 23;8.

Luck R*, Urban S*, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, Ruiz de Almodóvar C. VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. Elife. 2019 Dec 23;8.

Oliveira AM, Litke C, Paldy E, Hagenston AM, Lu J, Kuner R, Bading H, Mauceri D. Epigenetic control of hypersensitivity in chronic inflammatory pain by the de novo DNA methyltransferase Dnmt3a2. Mol Pain. 2019 Jan-Dec;15:1744806919827469. doi: 10.1177/1744806919827469.

Paldy E, Simonetti M, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R. The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via pathophysiological remodeling of neuronal and synaptic morphology. Mol Psychiatry doi:10.1038/s41380-019-0491-4, 2019.

Schlüter A, Aksan B, Diem R, Fairless R, Mauceri D. VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury. Mol Ther Methods Clin Dev. 2019 Dec 25;17:281-299. doi: 10.1016/j.omtm.2019.12.009.

Schlüter A, Aksan B, Fioravanti R, Valente S, Mai A, Mauceri D. Histone Deacetylases Contribute to Excitotoxicity-Triggered Degeneration of Retinal Ganglion Cells In Vivo. Mol Neurobiol. 2019 Dec;56(12):8018-8034. doi: 10.1007/s12035-019-01658-x.

Schlüter A, Rossberger S, Dannehl D, Janssen JM, Vorwald S, Hanne J, Schultz C, Mauceri D, Engelhardt M. Dynamic Regulation of Synaptopodin and the Axon Initial Segment in Retinal Ganglion Cells During Postnatal Development. Front Cell Neurosci. 2019 Jul 30;13:318. doi: 10.3389/fncel.2019.00318.

Tisch N*, Freire-Valls A*, Yerbes R*, Paredes I, La Porta S, Wang X, Martín-Pérez R, Castro L, Wong WW, Coultas L, Strilic B, Gröne HJ, Hielscher T, Mogler C, Adams RH, Heiduschka P, Claesson Welsh L, Mazzone M, López-Rivas A, Schmidt T, Augustin HG, Ruiz de Almodovar C. Caspase-8 modulates physiological and pathological angiogenesis during retina development. J Clin Invest. 2019 Dec 2;129(12):5092-5107.

Chandrasekar A, Aksan B, Heuvel FO, Förstner P, Sinske D, Rehman R, Palmer A, Ludolph A, Huber-Lang M, Böckers T, Mauceri D*, Knöll B*, Roselli F*. Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responses. Exp Neurol 2018; 302:34-45.* equal contribution.

Litke C., Bading H., Mauceri D. Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of Vascular Endothelial Growth Factor D. J Biol Chem 2018; 293:8196-8207.

Paredes I, Himmels P, Ruiz de Almodovar C. Neurovascular Communication during CNS Development. Dev Cell. 2018; 45:10-32.

Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodovar C, Martin-Villalba A. CNS Macrophages Control Neurovascular Development via CD95L. Cell Rep. 2017; 19:1378-139.

Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET & Ruiz de Almodovar C. Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017; 8:14583.

Wang X, Freire Valls A, Shermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann Lm Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodovar C. YAP/TAZ orchestrate VEGF signalling during developmental angiogenesis. Dev Cell. 2017; 42:462-478.

Schlumm F*, Mauceri D*, Freitag HE, Bading H. Nuclear calcium signalling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity. J Biol Chem 2013; 288:8074-84. *equal contribution.

Simonetti M*, Hagenston AM*, Vardeh D*, Freitag HE*, Mauceri D*, Lu J, Satagopam VP, Schneider R, Costigan M, Bading H, Kuner R. Nuclear calcium signalling in spinal neurons drives a genomic program required for persistent inflammatory pain. Neuron 2013; 77:43-57. *equal contribution.

Mauceri D, Freitag HE, Oliveira AM, Bengtson CP, Bading H. Nuclear calcium-VEGFD signalling controls maintenance of dendrite arborization necessary for memory formation. Neuron 2011; 71:117-30.

Ruiz de Almodovar C*, Fabre P*, Knevels E, Coulon C, Segura I, Haddick PCG, Aerts L, Delattin N, Strasser G, Oh WJ, Lange C, Vinckier S, Haigh JJ, Fouquet C, Henderson C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F* and Carmeliet P*. VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron 2011; 70: 966-78. *equal contribution.

Other publications:

Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Müller MK, de Palma M, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodovar C. (2021)The angiopoietin-Tie2 signaling axis serves as a neuro-glia-vessel communication pathway that regulates Purkinje cell dendritogenesis. Cell Reports  (accepted).