Publications – Heidelberg Pain Consortium

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Publications:

Spinal Cord Injury – neuropathic pain publications:

Sliwinski C, Heutehaus L, Taberner FJ, Weiss L, Kampanis V, Tolou-Dabbaghian B, Cheng X, Motsch M, Heppenstall P, Kuner R, Franz S, Lechner, SG, Weidner Norbert, Puttagunta R. Contribution of mechanoreceptors to spinal cord injury–induced mechanical allodynia. PAIN (2023):10.1097/j.pain.0000000000003139, December 27, 2023.

Jende JME, Heutehaus L, Preisner F, Verez Sola CM, Mooshage CM, Heiland S, Rupp R, Bendszus M, Weidner N, Kurz FT, Franz S. MR Neurography in spinal cord injury : Imaging findings and clinical significance. European Journal of Neurology. Accepted Dec. 2023.

Franz S, Heutehaus L, Tappe-Theodor A, Weidner N, Treede RD, Schuh-Hofer S. Noxious radiant heat evokes bi-component nociceptive withdrawal reflexes in spinal cord injured humans-A clinical tool to study neuroplastic changes of spinal neural circuits. Frontiers in Human Neuroscience. 2023 ;17:1141690. DOI: 10.3389/fnhum.2023.1141690.

Luz A, Rupp R, Ahmadi R, Weidner N. Beyond treatment of chronic pain: a scoping review about epidural electrical spinal cord stimulation to restore sensorimotor and autonomic function after spinal cord injury. Neurological Research and Practice. 2023 Apr;5(1):14. DOI: 10.1186/s42466-023-00241-z.

Chen J, Weidner N, Puttagunta R. The impact of activity-based interventions on neuropathic pain in experimental spinal cord injury. Cells. 11, 2022.

Franz S, Eck U, Schuld C, Heutehaus L, Wolf M, Wilder-Smith E, Schulte-Mattler W, Weber MA, Rupp R, Weidner N. Lower motoneuron dysfunction impacts spontaneous motor recovery in acute cervical spinal cord injury. J Neurotrauma. 2022. DOI: https://doi.org/10.1089/neu.2022.0181.

Hug A, Bernini A, Wang H, Lutti A, Jende JME, Böttinger M, Weber MA, Weidner N, Lang S. In chronic complete spinal cord injury supraspinal changes detected by quantitative MRI are confined to volume reduction in the caudal brainstem. Neuroimage Clin. 2021 Jun 10;31:102716.

Heutehaus L, Schuld C, Solinas D, Hensel C, Kämmerer T, Weidner N, Rupp R, Franz S (2021) Revisiting the Examination of Sharp/Dull Discrimination as Clinical Measure of Spinothalamic Tract Integrity. Front. Neurol. doi: 10.3389/fneur.2021.677888.

Hug A, Spingler T, Hensel C, Fichtner S, Daniel T, Heutehaus L, Wensing M, Rupp R, Weidner N. Goal attainment in mobility after acute rehabilitation of mobility-restricting paralysis syndromes with regard to the ambulatory therapeutic level of participation NeuroMoves : A German national multicenter observational cohort study. BMC Neurol. 2021 Apr 7;21(1):149.

Prang P, Schuld C, Rupp R, Hensel C, Weidner N. Influence of patient isolation due to colonization with multidrug-resistant organisms on functional recovery after spinal cord injury. PLoS One. 2021 Mar 26;16(3):e0249295.

Franz S, Heutehaus L, Weinand S, Weidner N, Rupp R, Schuld C. Theoretical and practical training improves knowledge of the examination guidelines of the International Standards for Neurological Classification of Spinal Cord Injury. Spinal Cord. 2020 Nov 17.

Franz S, Schulz B, Wang H, Gottschalk S, Grüter F, Friedrich J, Glaesener JJ, Bock F, Schott C, Müller R, Schultes K, Landmann G, Gerner HJ, Dietz V, Treede RD and Weidner N. (2019) Management of pain in individuals with spinal cord injury: Guideline of the German-Speaking Medical Society for Spinal Cord Injury. GMS German Medical Science. Vol. 17, ISSN 1612-3174.

Sliwinski C, Nees TA, Puttagunta R, Weidner N, Blesch A. (2018) Sensorimotor Activity Partially Ameliorates Pain and Reduces Nociceptive Fiber Density in the Chronically Injured Spinal Cord. J Neurotrauma. 35(18):2222-2238.

Franz M, Richner L, Wirz M, von Reumont A, Bergner U, Herzog T, Popp W, Bach K, Weidner N and Curt A. (2018) Physical therapy is targeted and adjusted over time for the rehabilitation of locomotor function in acute spinal cord injury interventions in physical and sports therapy. Spinal Cord. Feb;56(2):158-167.

Nees TA, Finnerup NB, Blesch A, Weidner N. (2017) Neuropathic pain after spinal cord injury: the impact of sensorimotor activity. Pain. 158(3):371-376.

Warner FM, Cragg JJ, Jutzeler CR, Röhrich F, Weidner N, Saur M, Maier DD, Schuld C; EMSCI Sites, Curt A, Kramer JK. (2017) Early Administration of Gabapentinoids Improves Motor Recovery after Human Spinal Cord Injury. Cell Rep.18(7):1614-1618.

Franz S, Schuld C, Wilder-Smith EP, Heutehaus L, Lang S, Gantz S, Schuh-Hofer S, Treede RD, Bryce TN, Wang H, Weidner N. (2017) Spinal Cord Injury Pain Instrument and painDETECT questionnaire: Convergent construct validity in individuals with Spinal Cord Injury. Eur J Pain. Nov;21(10):1642-1656.

Cragg JJ, Haefeli J, Jutzeler CR, Rohrich F, Weidner N, Saur M, Maier DD, Kalke YB, Schuld C, Curt A, and Kramer JK. (2016) Effects of Pain and Pain Management on Motor Recovery of Spinal Cord-Injured Patients: A Longitudinal Study. Neurorehab and Neural Repair. 30(8):753-61.

Nees TA, Tappe-Theodor A, Sliwinski C, Motsch M, Rupp R, Kuner R, Weidner N, Blesch A. (2016) Early-onset treadmill training reduces mechanical allodynia and modulates calcitonin gene-related peptide fiber density in lamina III/IV in a mouse model of spinal cord contusion injury. Pain. 157(3):687-697.

Spinal Cord Injury – non-neuropathic pain-related publications:

Kuehn N, Schwarz A, Beretta CA, Schwarte Y, Schmitt F, Motsch M, Weidner N, Puttagunta R. Intermediate gray matter interneurons in the lumbar spinal cord play a critical and necessary role in coordinated locomotion. Plos one. 2023 ;18(10):e0291740. DOI: 10.1371/journal.pone.0291740.

Wagner B, Weidner N, Hug A. Elevated high-sensitivity cardiac troponin T serum concentration in subjects with spinal cord injury. International Journal of Cardiology. 2023 Nov;391:131284. DOI: 10.1016/j.ijcard.2023.131284.

Balbinot G, Li G, Kalsi-Ryan S, Abel R, Maier D, Kalke YB, Weidner N, Rupp R, Schubert M, Curt A, Zariffa J. Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections. Nature Communications. 2023 Feb;14(1):723. DOI: 10.1038/s41467-023-36390-7.

Zhou L, Kong G, Palmisano I, Cencioni MT, Danzi M, De Virgiliis F, Chadwick JS, Crawford G, Yu Z, De Winter F, Lemmon V, Bixby J, Puttagunta R, Verhaagen J, Pospori C, Lo Celso C, Strid J, Botto M, Di Giovanni S. Reversible CD8 T cell-neuron cross-talk causes aging-dependent neuronal regenerative decline. Science (New York, N.Y.). 2022 May;376(6594):eabd5926. DOI: 10.1126/science.abd5926.

Zylla MM, Merle U, Vey JA, Korosoglou G, Hofmann E, Müller M, Herth F, Schmidt W, Blessing E, Göggelmann C, Weidner N, Fiedler MO, Weigand MA, Kälble F, Morath C, Leiner J, Kieser M, Katus HA, Thomas D. Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19. J Clin Med. 2021 Jan 2;10(1):133.

Timotius, IK, Bieler L, Couillard-Despres S, Sandner B, Garcia-Ovejero D, Labombarda F, Estrada V, Müller HW, Winkler J, Klucken J, Eskofier B, Weidner N, Puttagunta R. (2021) “Combination of Defined CatWalk Gait Parameters for Predictive Locomotion Recovery in Experimental Spinal Cord Injury Rat Models” eNeuro Mar 9;8(2):0497-20.2021.

Kampanis V, Tolou-Dabbaghian B, Zhou L, Roth W, Puttagunta R. (2021) “Cyclic Stretch of Either PNS or CNS Located Nerves Can Stimulate Neurite Outgrowth” Cells 10, no. 1: 32.

Kong G, Zhou L, Serger E, Palmisano I, De Virgiliis F, Hutson TH, Mclachlan E, Freiwald A, La Montanara P, Shkura K, Puttagunta R, Di Giovanni S. (2020) AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury. Nat Metab. Sep;2(9):918-933.

Keyl P, Schneiders M, Schuld C, Franz S, Hommelsen M, Weidner N and Rupp R. (2019) Differences in characteristics of error-related potentials between individuals with spinal cord injury and age- and sex-matched able-bodied controls. Frontiers in Neurology. 9:1192.

Hervera A, Zhou L, Palmisano I, McLachlan E, Kong G, Hutson TH, Danzi MC, Lemmon VP, Bixby JL, Matamoros-Angles A, Forsberg K, De Virgiliis F, Matheos DP, Kwapis J, Wood MA, Puttagunta R, Del Río JA, Di Giovanni S. (2019) PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure. EMBO J. May 22.

Schackel T., Kumar P., Günther M., Liu S., Brunner M., Sandner B., Puttagunta R., Müller R., Weidner N. and Blesch A. (2019) Peptides and Astroglia Improve the Regenerative Capacity of Alginate Gels in the Injured Spinal Cord. Tissue Eng Part A. Apr;25(7-8):522-537.

Sandner B, Puttagunta R, Motsch M, Bradke F, Ruschel J, Blesch A and Weidner N. (2018) Systemic epothilone D improves hindlimb function after spinal cord contusion injury in rats. Exp Neuro. 306:250-259.

Steeves J, Curt A, Mehra M, Rupp R, Blight A, Maier D, Jones L, Lammertse D, Abel R, Kirshblum S and Weidner N. (2018) The Spinal Cord Ability Ruler (SCAR) complements the Spinal Cord Independence Measure (SCIM). Spinal Cord.Jan 31.

Lou WP, Mateos A, Koch M, Klussman S, Yang C, Lu N, Kumar S, Limpert S, Göpferich M, Zschaetzsch M, Sliwinski C, Kenzelmann M, Seedorf M, Maillo C, Senis E, Grimm D, Puttagunta R, Mendez R, Liu K, Hassan BA and Martin-Villalba A. (2018) Regulation of adult CNS axonal regeneration by the post-transcriptional regulator Cpeb1. Front. in Mol. Neurosci. 10:445.

Liu S, Schackel T, Weidner N and Puttagunta R. (2018) Biomaterial-supported cell transplantation treatments for spinal cord injury: challenges and perspectives. Front. in Cell. Neurosci.11:430.

Liu S, Sandner B, Schackel T, Nicholson L, Chtarto A, Tenenbaum L, Puttagunta R, Müller R, Weidner N, and Blesch A. (2017) Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury. Acta Biomaterialia.Sep 15;60:167-180.

Reed R, Mehra M, Kirshblum S, Maier D, Lammertse D, Blight A, Rupp R, Jones L, Abel R, Weidner N; EMSCI Study Group; SCOPE, Curt A and Steeves J. (2017) Spinal cord ability ruler: an interval scale to measure volitional performance after spinal cord injury. Spinal Cord Aug;55(8):730-738.

Schuld C, Franz S, Brüggemann K, Heutehaus L, Weidner N, Kirshblum SC, Rupp R; EMSCI study group. (2016) International standards for neurological classification of spinal cord injury: impact of the revised worksheet (revision 02/13) on classification performance. J Spinal Cord Med. Sep;39(5):504-12.

Franz S, Kirshblum SC, Weidner N, Rupp R, Schuld C; EMSCI study group. (2016) Motor levels in high cervical spinal cord injuries: Implications for the International Standards for Neurological Classification of Spinal Cord Injury. J Spinal Cord Med. Sep;39(5):513-7.

Schuld C, Franz S, van Hedel HJ, Moosburger J, Maier D, Abel R, van de Meent H, Curt A, Weidner N; EMSCI study group, Rupp R. (2015) International standards for neurological classification of spinal cord injury: classification skills of clinicians versus computational algorithms. Spinal Cord. Apr;53(4):324-31.

Rupp R, Schliessmann D, Plewa H, Schuld C, Gerner HJ, Weidner N, Hofer EP, Knestel M. (2015) Safety and efficacy of at-home robotic locomotion therapy in individuals with chronic incomplete spinal cord injury: a prospective, pre-post intervention, proof-of-concept study. PLoS One.10 (3):e0119167.

Puttagunta R, Tedeschi A, Soria MG, Hervera A, Lindner R, Rathore KI, Gaub P, Joshi Y, Nguyen T, Schmandke A, Laskowski CJ, Boutillier AL, Bradke F, Di Giovanni S. (2014) PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system. Nat Commun. 5:3527.

Schuld C, Wiese J, Hug A, Putz C, Hedel HJ, Spiess MR, Weidner N, Rupp R. (2012) Computer implementation of the international standards for neurological classification of spinal cord injury for consistent and efficient derivation of its subscores including handling of data from not testable segments. J Neurotrauma. 29(3):453-61.

Joint publications with SFB PIs