Publications:
Pakalniskis J, Soares S, Rajan S, Vyshnevska A, Schmelz M, Solinski HJ, Rukwied R and Carr R. (2023) Human pain ratings to electrical sinusoids increase with cooling through a cold-induced increase in C-fibre excitability. Pain (in press)
Schneider T, Filip J, Soares S, Sohns K, Carr R, Rukwied R, Schmelz M. Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers. J Pain. 2023 Jan 18:S1526-5900(23)00017-2. doi: 10.1016/j.jpain.2023.01.009. Epub ahead of print. PMID: 36681314.
Liu S, Bonalume V, Gao Q, Chen JT, Rohr K, Hu J, Carr R. Pre-synaptic GABA(A) in NaV1.8(+) primary afferents is required for the development of punctate but not dynamic mechanical allodynia following CFA inflammation. Cells 2022 Aug 3;11(15):2390. doi: 10.3390/cells11152390.
Oehler B, Périer C, Martin V, Fisher A, Lezmi S, Kalinichev M, McMahon SB. Evaluation of recombinant botulinum neurotoxin type A1 efficacy in peripheral inflammatory pain in mice. Front Mol Neurosci. 15:909835, 2022.
Bonalume V, Caffino L, Castelnovo LF, Faroni A, Liu S, Hu J, Milanese M, Bonanno G, Sohns K, Hoffmann T, De Col R, Schmelz M, Fumagalli F, Magnaghi V, Carr R. Axonal GABAA stabilises excitability in unmyelinated sensory axons secondary to NKCC1 activity. J Physiol. 2021 Sep;599(17):4065-4084. doi: 10.1113/JP279664. Epub 2021 Jul 29.
Morelli, C., Castaldi, L., Brown, S.J., Streich, L.L., Websdale, A., Taberner, F.J., Cerreti, B., Barenghi, A., Blum, K.M., Sawitzke, J., Frank, T., Steffens, L.K., Doleschall, B., Serrao, J., Ferrarini, D., Lechner, S.G., Prevedel, R., Heppenstall, P.A., 2021. Identification of a population of peripheral sensory neurons that regulates blood pressure. Cell Rep 35, 109191. https://doi.org/10.1016/j.celrep.2021.109191
Schwaller, F., Bégay, V., García-García, G., Taberner, F.J., Moshourab, R., McDonald, B., Docter, T., Kühnemund, J., Ojeda-Alonso, J., Paricio-Montesinos, R., Lechner, S.G., Poulet, J.F.A., Millan, J.M., Lewin, G.R., 2021. USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans. Nat Neurosci 24, 74–81. https://doi.org/10.1038/s41593-020-00751-y
Bonalume V, Caffino L, Castelnovo LF, Faroni A, Giavarini F, Liu S, Caruso D, Schmelz M, Fumagalli F, Carr RW, Magnaghi V. Schwann Cell Autocrine and Paracrine Regulatory Mechanisms, Mediated by Allopregnanolone and BDNF, Modulate PKCε in Peripheral Sensory Neurons. Cells. 2020 Aug 11;9(8):1874. doi: 10.3390/cells9081874. PMID: 32796542
Carr RW, Frings S. Neuropeptides in Sensory System Signaling. Cell Tiss Res 2018; DOI: 10.1007/s00441-018-2946-3.
Narayanan, P., Hütte, M., Kudryasheva, G., Taberner, F.J., Lechner, S.G., Rehfeldt, F., Gomez-Varela, D., Schmidt, M., 2018. Myotubularin related protein-2 and its phospholipid substrate PIP2control Piezo2-mediated mechanotransduction in peripheral sensory neurons. Elife 7. https://doi.org/10.7554/eLife.32346
Klein AH, Vyshnevska A, Hartke TV, De Col R, Mankowski JL, Turnquist B, Bosmans F, Reeh PW, Schmelz M, Carr RW*, Ringkamp M*. Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves. J Neurosci 2017;37:5204-5214.
Genovese F, Bauersachs HG, Grasser I, Kupke J, Magin L, Daiber P, Nakajima J, Mohrlen F, Messlinger K, Frings S. Possible role of calcitonin gene-related peptide in trigeminal modulation of glomerular microcircuits of the rodent olfactory bulb. Eur J Neurosci 2016;45:587-600.
Genovese F, Thews M, Mohrlen F, Frings S. Properties of an optogenetic model for olfactory stimulation. J Physiol 2016;594:3501-3516.
Morley SJ, Qi Y, Iovino L, Andolfi L, Guo D, Kalebic N, Castaldi L, Tischer C, Portulano C, Bolasco G, Shirlekar K, Fusco CM, Asaro A, Fermani F, Sundukova M, Matti U, Reymond L, De Ninno A, Businaro L, Johnsson K, Lazzarino M, Ries J, Schwab Y, Hu J*, Heppenstall PA*. Acetylated tubulin is essential for touch sensation in mice. Elife 2016;13:5. (* joint corresponding author)
Jonas R, Klusch A, Schmelz M, Petersen M, Carr RW. Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata. PLoS One 2015;10:e0139107.
Qi Y, Andolfi L, Frattini F, Mayer F, Lazzarino M, Hu J. Membrane stiffening by STOML3 facilitates mechanotransduction in sensory neurons. Nat Comm 2015;6:8512.
Chen JT, Guo D, Campanelli D, Frattini F, Mayer F, Zhou L, Kuner R, Heppenstall PA, Knipper M, Hu J. Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction. Nat Comm 2014;5:5331.
Guo D, Hu J. Spinal presynaptic inhibition in pain control. Neuroscience 2014;283:95-106.
Chiang LY, Poole K, Oliveira BE, Duarte N, Sierra YA, Bruckner-Tuderman L, Koch M, Hu J,* Lewin GR*. Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons. Nat Neurosci 2011;14:993- 1000. (* joint corresponding author)
Joint publications:
Agarwal, N., Taberner, F.J., Rangel Rojas, D., Moroni, M., Omberbasic, D., Njoo, C., Andrieux, A., Gupta, P., Bali, K.K., Herpel, E., Faghihi, F., Fleming, T., Dejean, A., Lechner, S.G., Nawroth, P.P., Lewin, G.R., Kuner, R., 2020. SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes. Neuron 107, 1141-1159.e7. https://doi.org/10.1016/j.neuron.2020.06.037
Jonas, R., Prato, V., Lechner, S.G., Groen, G., Obreja, O., Werland, F., Rukwied, R., Klusch, A., Petersen, M., Carr, R.W., Schmelz, M., 2020. TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors. Front Cell Neurosci. 2020 Feb 7;14:13. doi: 10.3389/fncel.2020.00013. eCollection 2020. PMID: 32116559 https://doi.org/10.3389/fncel.2020.00013
Jonas R, Namer B, Schnakenberg M, Soares S, Pakalniskis J, Carr R, Schmelz M, Rukwied R. Sympathetic efferent neurons are less sensitive than nociceptors to 4 Hz sinusoidal stimulation. Eur J Pain. 2020 Jan;24(1):122-133. doi: 10.1002/ejp.1467. Epub 2019 Aug 27. PMID: 31392805
Rukwied R, Thomas C, Obreja O, Werland F, Kleggetveit IP, Jorum E, Carr RW, Namer B, Schmelz M. Slow depolarizing stimuli differentially activate mechanosensitive and silent C nociceptors in human and pig skin. Pain. 2020 Sep 1;161(9):2119-2128. doi: 10.1097/j.pain.0000000000001912.
Taberner, F.J., Prato, V., Schaefer, I., Schrenk-Siemens, K., Heppenstall, P.A., Lechner, S.G., 2019. Structure-guided examination of the mechanogating mechanism of PIEZO2. Proc. Natl. Acad. Sci. U.S.A. 116, 14260–14269. https://doi.org/10.1073/pnas.1905985116