People:

PhD student: Simon Desch – 

Study nurse: Astrid Wolf – 

MD students:

Hongcai Liu – 

 

Sofia Doubrovinskaia – 

Anja Thanner – 

MSc students:

Henry.Schirok – 

Beitz, Clara – 

Victor Madariaga Rivera – 

Melanie Spindler – (Univ. Oldenburg, Germany)

Associates :

MD: Ahmadi Rezvan (associate member)

MD: AwaisAkbar Bajwa  – 

Postdoc:Christopher Milde –(Univ. Landau, Germany)

PhD student:  Yuanyuan Lyu – (Shanghai Jiao Tong University, China)

Prof. Dr. Dr. h.c. Herta Flor

Department of Clinical Psychology and Neuropsychology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University

Dr. Jamila Andoh

Department of Clinical Psychology and Neuropsychology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University

Neural circuits involved in phantom limb pain

 

fig1
Virtual Reality

The causal role of neuroplastic alterations in brain circuits and interacting peripheral factors in shaping the experience of phantom limb pain (PLP) is not yet well understood. In the new funding period we plan to complement the examination of amputees pre and post amputation with an analysis of patients with pain that have a high likelihood of having an amputation.

fig1
real-time fMRIy
fig1
transcranial magnetic stimulation

Since pre-amputation pain is a major determinant for PLP and also a major determinant for amputation in diabetic patients, we will test diabetic patients at risk for an amputation well before the amputation and follow them to assess central and peripheral physiological as well as psychological predictors of both amputation and PLP.

fig1
transcranial alternating current stimulation

We will also use virtual and augmented reality applications in addition to electromyographic recordings from the residual limb to model the differential role of somatosensory, motor and visual inputs from the phantom for brain changes and PLP.

fig1
structural changes

 

Further, we will ask how the PLP percept can be modulated by altering activation patterns and cortical rhythms employing fMRI neurofeedback and non-invasive brain stimulation techniques.

fig1
functional maps of the primary
somatosensory and motor cortices
Publications

Andoh J, Milde C, Tsao JW, Flor H. Cortical plasticity as a basis of phantom limb pain: Fact or fiction? Neuroscience2017;S0306-4522(17)30809-6.

Andoh J, Flor H. Ursache der Phantomschmerzen: eine dynamische Netzwerksperspektive [Origin of phantom limb pain: A dynamic network perspective]. Neuroforum, Special Issue, 2017;23, 149-156.

Andoh J, Diers M, Milde C, Köppe C, Kleinböhl D, Flor H. Neural correlates of evoked phantom limb sensations. Biological Psychology 2017;126:89-97.

Andoh J,Matsushita R, Zatorre RJ. Asymmetric Interhemispheric Transfer in the Auditory Network: Evidence from TMS, Resting-State fMRI, and Diffusion Imaging. J Neurosci. 2015;35(43):14602-11.

Davis KD, Flor H, Greely HT, Iannetti GD, Mackey S, Ploner M, Pustilnik A, Tracey I, Treede RD, Wager TD. Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations. Nat Rev Neurol. 2017;13(10):624-638.

De Nunzio AM, Schweisfurth MA, Ge N, Falla D, Hahne JM, Gödecke K, Petzke F, Siebertz M, Dechent P, Weiss T, Flor H, Graimann B, Aszmann O, Farina D. Relieving Phantom Limb Pain with Multimodal Sensory-Motor Training. J Neural Eng. 2019; In press. doi: 10.1088/1741-2552/aae271.

Guo X, Lin Z, Lyu Y, Bekrater-Bodmann R, Flor H, Tong S. The Effect of Prosthesis Use on Hand Mental Rotation After Unilateral Upper-Limb Amputation. IEEE Trans Neural Syst Rehabil Eng 2017;25(11):2046-2053.

Kuner RFlor H. Structural plasticity and reorganisation in chronic pain. Nat. Rev. Neurosci 2016;18(1):20-30. 

Larbig W*, Andoh J*,Huse E, Stahl-CorinoD, Montoya P, Seltzer Z* & Flor H*.Pre- and postoperative predictors of phantom limb pain, Neuroscience Letters,2019; *equal contribution. In press. https://authors.elsevier.com/tracking/article/details.do?aid=33962&jid=NSL&surname=Flor.

Lyu Y, Guo X, Bekrater-Bodmann R, Flor H,Tong S. Phantom limb perception interferes with motor imagery after unilateral upper-limb amputation. Sci Rep 2016;16;6:21100.

Tan LL, Pelzer P, Heinl C, Tang W, Gangadharan V, Flor H, Sprengel R, Kuner T, Kuner R. A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity. Nat Neurosci. 2017;20(11):1591-1601. 

Links:

http://www.sfb636.de/

 

People: 

PhD student: Simon Desch – 

Study nurse: Astrid Wolf – 

MD students:

Hongcai Liu – 

Sofia Doubrovinskaia – 

Anja Thanner – 

MSc students:

Henry.Schirok – 

Beitz, Clara – 

Victor Madariaga Rivera – 

Melanie Spindler – (Univ. Oldenburg, Germany)

Associates :

Medical Doctors:

Ahmadi Rezvan (associate member)

AwaisAkbar Bajwa  – 

 

Postdoc: Christopher Milde –(Univ. Landau, Germany)

PhD students:  

Yuanyuan Lyu – (Shanghai Jiao Tong University, China)

PhD student: Mikkel Thøgersen – (Aalborg university, Denmark)

PhD: Max Jair Ortiz Catalan– (University of Technology, Göteborg)

PhD student:Eva Lendaro –(University of Technology, Göteborg visit January 15th-18th2019)

Others:

Nina Stockfleth Buch –(Aarhus C Denmark). Talk on Monday January 28th2019

Christian Cipriani – (BioRobotics Institute of the Scuola Superiore Sant'Anna, Pisa). 

Marcin Czub – (Institute of Psychology, University of Wroclaw, Wroclaw, Poland). 

Maide Bucolo – (Univ. Catania, Italy). 

Wolfgang Larbig – (University of Tuebingen, Germany)

Pedro Montoya –Palma de Mallorca, Spain

News

  • Congratulations!

    The Heidelberg Pain Consortium goes into the second funding period.

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  • Valery Grinevich appointed Professor for Neuropeptide research in psychiatry

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  • The Challenge of Chronic Pain Conference

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  • Preparatory Retreat

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  • Upcoming ICD-11 Classification of Chronic Pain

    The upcoming ICD-11 Classification of Chronic Pain is featured in Pain Research Forum

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